TPDB

TPDB ID TPDB77562

Peptide_Name

LinS

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 20-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

YaGF-(thiourea)A-NH2

FASTA

>TPDB77562|Blood-Brain Barrier|length=20
YaGF-(thiourea)A-NH2

Formula C66H95N21O19

Absent Amino Acids DCQLKMPSWV

Common Amino Acids A

Mass 1486.61

PI 7.92

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 6

Net Charge +0

Boman Index 2.43

Hydrophobicity -0.380

Aliphatic Index 34.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 100.23

Polar Residues 3

number

3

A

1

R

1

N

0

D

0

C

1

E

0

Q

1

G

2

H

1

I

0

L

0

K

0

M

1

F

0

P

0

S

1

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 3 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 2 I: 1 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0

Length

20

Formula

C66H95N21O19

Mass

1486.61

PI

7.92

Net Charge

+0

Boman Index

2.43

Hydrophobicity

-0.380

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-(D)Ala-Gly-Phe-(thiourea)Ala-NH2

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.07 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 8.50%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 91.50%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00045 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02236 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous