TPDB

TPDB ID TPDB77555

Peptide_Name

Oncocin

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 23-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

VDKPPYLPRPRPPRRIYNR-NH2

FASTA

>TPDB77555|Blood-Brain Barrier|length=23
VDKPPYLPRPRPPRRIYNR-NH2

Formula C119H189N41O28

Absent Amino Acids ACEQGMFSTW

Common Amino Acids P

Mass 2642.07

PI 11.84

Basic Residues 7

Acidic Residues 1

Hydrophobic Residues 5

Net Charge +5

Boman Index 8.09

Hydrophobicity -1.730

Aliphatic Index 46.52

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 112.79

Polar Residues 4

number

0

A

5

R

2

N

1

D

0

C

0

E

0

Q

0

G

1

H

1

I

1

L

1

K

0

M

0

F

6

P

0

S

0

T

0

W

2

Y

1

V

Amino Acid Distribution

A: 0 R: 5 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 1 M: 0 F: 0 P: 6 S: 0 T: 0 W: 0 Y: 2 V: 1

Length

23

Formula

C119H189N41O28

Mass

2642.07

PI

11.84

Net Charge

+5

Boman Index

8.09

Hydrophobicity

-1.730

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Val-Asp-Lys-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Arg-Arg-Ile-Tyr-Asn-Arg-NH2

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.002 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 82%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 18%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00044 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02584 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous