Back to search

Peptide record

TPDB77545

Substance P Blood-Brain Barrier modified_plain modified
15 amino acids
Basic Information
TPDB77545
Substance P
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 15-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation
Sequence
RPKPQQFFGLM-NH2
Physicochemical Analysis
C73H110N22O17S1
ADCEISTWYV
QFP
1599.87
11.49
3
0
4
+2
2.20
-0.960
26.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
2
Q
1
G
1
H
0
I
1
L
1
K
1
M
2
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 0 L: 1 K: 1 M: 1 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C73H110N22O17S1
1599.87
11.49
+2
2.20
-0.960
Linear
Similarity
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
O=C(N)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2N(C(=O)C(NC(=O)C1N(C(=O)C(N)CCCNC(=[N@H])N)CCC1)CCCCN)CCC2)CCC(=O)N)CCC(=O)N)Cc3ccccc3)Cc4ccccc4)CC(C)C)CCSC
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
258

Assay & Model

Origin/Source
Blood/brain ratio

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intracarotid injection
Permeability
Direct iodination
Additional Detail Fields 1 fields
Intracarotid injection