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Peptide record

TPDB77540

Orexin A Blood-Brain Barrier modified_plain modified
40 amino acids
Basic Information
TPDB77540
Orexin A
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 40-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation Chemical: Cys6-Cys12, Cys7-Cys14
Sequence
Pyr-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2
Physicochemical Analysis
C177H282N56O50S4
MFWV
L
4122.77
8.30
7
2
12
+2
5.74
-0.315
75.75
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
3230
78.35
12
Residue Composition
number
3
A
3
R
2
N
1
D
4
C
1
E
1
Q
3
G
3
H
1
I
6
L
1
K
0
M
0
F
3
P
1
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 2 D: 1 C: 4 E: 1 Q: 1 G: 3 H: 3 I: 1 L: 6 K: 1 M: 0 F: 0 P: 3 S: 1 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
40
C177H282N56O50S4
4122.77
8.30
+2
5.74
-0.315
Cys6-Cys12, Cys7-Cys14
Linear
Similarity
Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-leu-Thr-Leu-NH2
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.0003091 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

human,pig,mouse,rat,porcine
Intravenous
non saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
30.7 min

Assay & Model

HPLC
Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

human,pig,mouse,rat,porcine
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
87.3 %/g

Assay & Model

HPLC
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

human,pig,mouse,rat,porcine
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.63

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

human,pig,mouse,rat,porcine
Direct iodination
Additional Detail Fields 1 fields
Intravenous