TPDB

TPDB ID TPDB77539

Peptide_Name

cationic AVP4-9

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 19-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation Chemical: Cys3A-Cys3B

Sequence

Pyr-N(CPHR)CPRG-NH2

FASTA

>TPDB77539|Blood-Brain Barrier|length=19
Pyr-N(CPHR)CPRG-NH2

Formula C70H107N29O18S2

Absent Amino Acids ADEQILKMFSTWV

Common Amino Acids RP

Mass 1706.92

PI 9.92

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +3

Boman Index 5.13

Hydrophobicity -1.495

Aliphatic Index 0.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 1615

Absorbance 280nm 94.61

Polar Residues 5

number

0

A

3

R

2

N

0

D

2

C

0

E

0

Q

1

G

2

H

0

I

0

L

0

K

0

M

0

F

3

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 3 N: 2 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

19

Formula

C70H107N29O18S2

Mass

1706.92

PI

9.92

Net Charge

+3

Boman Index

5.13

Hydrophobicity

-1.495

Chemical_Modification

Cys3A-Cys3B

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Pyr-Asn-(Cys-Pro-His-Arg)-Cys-Pro-Arg-Gly-NH2

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0186 ml/g

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response Capillary depletion (capillary/serum)

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.406 ml/g

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response Capillary depletion (parenchyma/serum)

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 4.38%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 95.62%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00031 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Saturable

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous