TPDB

TPDB ID TPDB77537

Peptide_Name

Luteinizing hormone-

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 13-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

Modified, details unspecified

Sequence

Pyr-HWSYGLRPG

FASTA

>TPDB77537|Blood-Brain Barrier|length=13
Pyr-HWSYGLRPG

Formula C70H97N21O16

Absent Amino Acids ANDCEQIKMFTV

Common Amino Acids RGPY

Mass 1488.67

PI 10.25

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +2

Boman Index -0.66

Hydrophobicity -1.285

Aliphatic Index 30.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 8480

Absorbance 280nm 569.64

Polar Residues 3

number

0

A

2

R

0

N

0

D

0

C

0

E

0

Q

2

G

1

H

0

I

1

L

0

K

0

M

0

F

2

P

1

S

0

T

1

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 1 Y: 2 V: 0

Length

13

Formula

C70H97N21O16

Mass

1488.67

PI

10.25

Net Charge

+2

Boman Index

-0.66

Hydrophobicity

-1.285

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly

SMILES

O=C(NCC(=O)O)[C@H]6N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]1NC(=O)CC1)Cc2ncnc2)Cc4c3ccccc3nc4)CO)Cc5ccc(O)cc5)CC(C)C)CCCNC(=[N@H])N)CCC6

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 15 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.046 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01251 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional flux rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

In Vivo Mode of Delivery in situ brain perfusion

Transport Type Saturable

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02 µL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Permeability surface area cofficient

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

In Vivo Mode of Delivery in situ brain perfusion

Transport Type Saturable

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.43

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -1.35

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 126

Assay & Model

Animal Model Origin/Source

Response Blood/brain ratio

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

In Vivo Mode of Delivery Intracarotid injection

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

in situ brain perfusion Intracarotid injection