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Peptide record

TPDB77536

Thyrotropin releasin Blood-Brain Barrier modified_plain modified
6 amino acids
Basic Information
TPDB77536
Thyrotropin releasin
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 6-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Chemical modification N-terminal: C-terminal modification
Sequence
Pyr-HP
Physicochemical Analysis
C31H44N10O7
ANDCEQGILKMFSTWV
P
668.75
9.88
2
0
1
+1
1.73
-2.033
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
222.80
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
6
C31H44N10O7
668.75
9.88
+1
1.73
-2.033
Chemical modification
Linear
C-terminal modification
Similarity
Pyr-His-Pro
O=C(N1[C@H](C(=O)O)CCC1)[C@H](NC(=O)[C@H]2NC(=O)CC2)Cc3ncnc3
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
5.54%

Assay & Model

BUI method
Origin/Source
BUI

Source & Reference

NA
B3Pdb

Other

human,mouse,rat
non saturable
H3/C14
Evidence 2 Activity

Activity

Blood-Brain Barrier
3.42%

Assay & Model

BUI method
Origin/Source
BUI

Source & Reference

NA
B3Pdb

Other

human,mouse,rat
non saturable
H3/C14
Evidence 3 Activity

Activity

Blood-Brain Barrier
260%

Assay & Model

BUI method
Origin/Source
BUI

Source & Reference

NA
B3Pdb

Other

human,mouse,rat
non saturable
H3/C14
Evidence 4 Activity

Activity

Blood-Brain Barrier
3.39%

Assay & Model

BUI method
Origin/Source
BUI

Source & Reference

NA
B3Pdb

Other

human,mouse,rat
non saturable
H3/C14