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Peptide record

TPDB77533

(3-methyl-His²) Thyr Blood-Brain Barrier modified_plain modified
10 amino acids
Basic Information
TPDB77533
(3-methyl-His²) Thyr
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 10-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
Pyr-(Me)HP
Physicochemical Analysis
C41H60N12O11S1
ANDCQGILKFSTWV
P
929.06
7.77
2
1
2
+0
3.52
-1.380
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
160.38
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
0
Q
0
G
1
H
0
I
0
L
0
K
1
M
0
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 1 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
10
C41H60N12O11S1
929.06
7.77
+0
3.52
-1.380
Linear
Similarity
Pyr-(Me)His-Pro
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
-2

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

H3/C14
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.00115 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Intravenous
Saturable
H3/C14
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00845 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Intravenous
Saturable
H3/C14
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.13 %/g

Assay & Model

Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

Intravenous
Permeability
H3/C14
Additional Detail Fields 1 fields
Intravenous