Back to search

Peptide record

TPDB77530

Melanocyte-stimulati MIF-1 Blood-Brain Barrier modified_plain modified

7 amino acids

TPDB ID TPDB77530

Peptide_Name

Melanocyte-stimulati MIF-1

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 7-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

PLG-NH2

FASTA

>TPDB77530|Blood-Brain Barrier|length=7
PLG-NH2

Formula C23H36N8O7

Absent Amino Acids ARDCEQIKMFSTWYV

Common Amino Acids NGHLP

Mass 536.59

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +0

Boman Index 1.28

Hydrophobicity -0.700

Aliphatic Index 55.71

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C23H36N8O7

Mass

536.59

7.85

Net Charge

Boman Index

1.28

Hydrophobicity

-0.700

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Pro-Leu-Gly-NH2

SMILES

CC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00234 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional flux rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine

In Vivo Mode of Delivery in situ brain perfusion

Transport Type Saturable

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0189 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial distribution vaolume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine

In Vivo Mode of Delivery in situ brain perfusion

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00000039 cm/s

Assay & Model

Animal Model Origin/Source

Response permiability constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine

In Vivo Mode of Delivery in situ brain perfusion

Transport Type Permeability

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.089 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 173 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 112 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.7

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine

Label Direct iodination

Evidence 8 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0000916667 cm/s

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Permeability coefficient

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human,bovine

Transport Type Saturable

Evidence 9 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 405 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Permeability

Label H3/C14

Evidence 10 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00074 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Permeability

Label H3/C14

Evidence 11 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0237 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intravenous

Transport Type partially saturable

Label H3/C14

Evidence 12 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.0173 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label H3/C14

In_Vivo_Mode_of_Delivery

in situ brain perfusion Intravenous