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Peptide record

TPDB77519

Pituitary adenylate Blood-Brain Barrier modified_plain modified
42 amino acids
Basic Information
TPDB77519
Pituitary adenylate
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 42-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2
Physicochemical Analysis
C213H343N67O57S1
CEPW
K
4786.54
10.79
13
2
15
+9
10.25
-1.119
55.71
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5960
124.52
12
Residue Composition
number
3
A
4
R
2
N
2
D
0
C
0
E
2
Q
2
G
2
H
1
I
2
L
7
K
1
M
1
F
0
P
3
S
1
T
0
W
4
Y
3
V
Amino Acid Distribution
A: 3 R: 4 N: 2 D: 2 C: 0 E: 0 Q: 2 G: 2 H: 2 I: 1 L: 2 K: 7 M: 1 F: 1 P: 0 S: 3 T: 1 W: 0 Y: 4 V: 3
Chemical Descriptors
42
C213H343N67O57S1
4786.54
10.79
+9
10.25
-1.119
Linear
Similarity
His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCCN)C(=O)O
Evidence Records 7 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.0153 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

human,bovine,mouse,rat,porcine
Intravenous
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0107 ml/g

Assay & Model

Origin/Source
Initial distribution volume

Source & Reference

NA
B3Pdb

Other

human,bovine,mouse,rat,porcine
Intravenous
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
22.3 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

human,bovine,mouse,rat,porcine
Saturable
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
58.9 %/g

Assay & Model

Efflux study ICU
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb

Other

human,bovine,mouse,rat,porcine
Permeability
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
0.031 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

human,bovine,mouse,rat,porcine
Saturable
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
0.82 min

Assay & Model

HPLC
Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

human,bovine,mouse,rat,porcine
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
-2.26

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

human,bovine,mouse,rat,porcine
Direct iodination
Additional Detail Fields 1 fields
Intravenous