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Peptide record

TPDB77516

Exendin-4-NH2 Blood-Brain Barrier modified_plain modified
43 amino acids
Basic Information
TPDB77516
Exendin-4-NH2
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 43-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation
Sequence
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Physicochemical Analysis
C194H294N54O64S1
CY
EGS
4438.85
4.84
5
6
11
-3
13.64
-0.784
47.67
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5500
123.91
10
Residue Composition
number
2
A
1
R
2
N
1
D
0
C
5
E
1
Q
5
G
2
H
1
I
3
L
2
K
1
M
2
F
4
P
5
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 1 C: 0 E: 5 Q: 1 G: 5 H: 2 I: 1 L: 3 K: 2 M: 1 F: 2 P: 4 S: 5 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
43
C194H294N54O64S1
4438.85
4.84
-3
13.64
-0.784
Linear
Similarity
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O) NC(CCCCN)C(=O)NC(CC(=O)N)C(=O)NCC(=O)NCC(=O)N3CCCC3C(=O)NC(CO)C(=O)NC (CO)C(=O)NCC(=O)NC(C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N6CCCC6C(=O)NC(CO)C(= O)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C) C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CCC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C (CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC8=CC=CC=C8)NC(=O)C(C(C)O)NC (=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC9=CN=CN9)N
Evidence Records 5 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
20.22%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
79.78%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.0183 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(brain/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.0146 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(parenchyma/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
0.0037 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(capillary/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination