TPDB

TPDB ID TPDB77508

Peptide_Name

Apidaecin Api137

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 23-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

Modified, details unspecified

Sequence

Guan-ONNRPVYIPRPRPPHPRL

FASTA

>TPDB77508|Blood-Brain Barrier|length=23
Guan-ONNRPVYIPRPRPPHPRL

Formula C103H165N37O25

Absent Amino Acids DCEQKMFSTW

Common Amino Acids P

Mass 2321.68

PI 12.40

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +4

Boman Index 6.26

Hydrophobicity -1.248

Aliphatic Index 50.87

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 64.18

Polar Residues 4

number

1

A

4

R

3

N

0

D

0

C

0

E

0

Q

1

G

1

H

1

I

1

L

0

K

0

M

0

F

6

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 1 R: 4 N: 3 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 1 K: 0 M: 0 F: 0 P: 6 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

23

Formula

C103H165N37O25

Mass

2321.68

PI

12.40

Net Charge

+4

Boman Index

6.26

Hydrophobicity

-1.248

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Guan-Orn-Asn-Asn-Arg-Pro-Va-Tyr-Ile-Pro-Arg-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.022 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 23%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 77%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00073 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02343 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous