TPDB

TPDB ID TPDB77505

Peptide_Name

Drosocin Pro5Hyp (un

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 22-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

Modified, details unspecified

Sequence

GKPR-Hyp-YSPRPTSHPRPIR

FASTA

>TPDB77505|Blood-Brain Barrier|length=22
GKPR-Hyp-YSPRPTSHPRPIR

Formula C108H167N37O26

Absent Amino Acids ANDCEQLMFWV

Common Amino Acids P

Mass 2399.75

PI 11.96

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +5

Boman Index 7.07

Hydrophobicity -1.759

Aliphatic Index 17.73

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 124.18

Polar Residues 5

number

0

A

4

R

0

N

0

D

0

C

0

E

0

Q

1

G

2

H

1

I

0

L

1

K

0

M

0

F

6

P

2

S

1

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 1 L: 0 K: 1 M: 0 F: 0 P: 6 S: 2 T: 1 W: 0 Y: 2 V: 0

Length

22

Formula

C108H167N37O26

Mass

2399.75

PI

11.96

Net Charge

+5

Boman Index

7.07

Hydrophobicity

-1.759

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Gly-Lys-Pro-Arg-4t-Hyp-Tyr-Ser-Pro-Arg-Pro-Thr-Ser-His-Pro-Arg-Pro-Ile-Arg-Val

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.079 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 33%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 67%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00037 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01957 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous