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Peptide record

TPDB77494

Doxorubicin-(D)-SynB Blood-Brain Barrier modified_plain modified
29 amino acids
Basic Information
TPDB77494
Doxorubicin-(D)-SynB
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 29-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Chemical modification N-terminal: C-terminal modification
Sequence
Doxorubicin-linker-RRLSYSRRRF
Physicochemical Analysis
C122H210N46O32S1
AQGHMPTWV
R
2865.36
12.02
8
2
7
+6
6.65
-0.893
67.24
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1490
52.00
6
Residue Composition
number
0
A
7
R
2
N
1
D
1
C
1
E
0
Q
0
G
0
H
3
I
2
L
1
K
0
M
1
F
0
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 2 D: 1 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 1 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
29
C122H210N46O32S1
2865.36
12.02
+6
6.65
-0.893
Chemical modification
Linear
C-terminal modification
Similarity
Doxorubicin-linker-(D)Arg-(D)Arg-(D)Leu-(D)Ser-(D)Tyr-(D)Ser-(D)Arg-(D)Arg-(D)Arg-(D)Phe
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.9618 ml/g

Assay & Model

Origin/Source
Volume of donor compartment

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
in situ brain perfusion
Permeability
H3/C14
Additional Detail Fields 1 fields
in situ brain perfusion