TPDB

TPDB ID TPDB77492

Peptide_Name

SKB P5 (12)

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 17-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

Dmt-rF-(NMe)K-NH2

FASTA

>TPDB77492|Blood-Brain Barrier|length=17
Dmt-rF-(NMe)K-NH2

Formula C58H91N19O19S2

Absent Amino Acids ACQGILPSWYV

Common Amino Acids NM

Mass 1422.60

PI 7.82

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 3

Net Charge +0

Boman Index 5.40

Hydrophobicity -1.159

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

0

A

1

R

2

N

1

D

0

C

1

E

0

Q

0

G

1

H

0

I

0

L

1

K

2

M

1

F

0

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 2 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 1 M: 2 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

17

Formula

C58H91N19O19S2

Mass

1422.60

PI

7.82

Net Charge

+0

Boman Index

5.40

Hydrophobicity

-1.159

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Dmt-D-Arg-Phe-(NMe)Lys-NH2

SMILES

O=C(N)[C@H](N(C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)C)CCCCN

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 24.76 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.028 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 25.95%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 74.05%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01811 ml/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant,initial

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02199 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0001458 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous