TPDB

TPDB ID TPDB77490

Peptide_Name

AN110 (14)

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 20-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

Dmt-D-Cit-F-NMeK-NH2

FASTA

>TPDB77490|Blood-Brain Barrier|length=20
Dmt-D-Cit-F-NMeK-NH2

Formula C69H107N19O25S3

Absent Amino Acids ARQGLPSWYV

Common Amino Acids NDMT

Mass 1698.90

PI 4.30

Basic Residues 2

Acidic Residues 3

Hydrophobic Residues 4

Net Charge -2

Boman Index 5.41

Hydrophobicity -0.620

Aliphatic Index 19.50

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 5

number

0

A

0

R

2

N

2

D

1

C

1

E

0

Q

0

G

1

H

1

I

0

L

1

K

2

M

1

F

0

P

0

S

2

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 2 D: 2 C: 1 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 1 M: 2 F: 1 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0

Length

20

Formula

C69H107N19O25S3

Mass

1698.90

PI

4.30

Net Charge

-2

Boman Index

5.41

Hydrophobicity

-0.620

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Dmt-D-Cit-Phe-NMeLys-NH2

SMILES

Dmt-D-Cit-Phe-NMeLys-NH2

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 69.31 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 21.84%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 78.16%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01135 ml/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant,initial

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01713 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0003434 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous