TPDB

TPDB ID TPDB77478

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 159-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

Modified, details unspecified

Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

FASTA

>TPDB77478|Blood-Brain Barrier|length=159
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Formula C558H877N141O160S1

Absent Amino Acids DCQKFW

Common Amino Acids L

Mass 12153.01

PI 5.25

Basic Residues 10

Acidic Residues 10

Hydrophobic Residues 63

Net Charge -5

Boman Index 7.85

Hydrophobicity 0.378

Aliphatic Index 95.22

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 13410

Absorbance 280nm 110.34

Polar Residues 24

number

17

A

4

R

2

N

0

D

0

C

10

E

0

Q

11

G

6

H

5

I

25

L

0

K

1

M

0

F

6

P

11

S

2

T

0

W

9

Y

6

V

Amino Acid Distribution

A: 17 R: 4 N: 2 D: 0 C: 0 E: 10 Q: 0 G: 11 H: 6 I: 5 L: 25 K: 0 M: 1 F: 0 P: 6 S: 11 T: 2 W: 0 Y: 9 V: 6

Length

159

Formula

C558H877N141O160S1

Mass

12153.01

PI

5.25

Net Charge

-5

Boman Index

7.85

Hydrophobicity

0.378

Evidence 1 Activity

Source & Reference

Database Source NA