TPDB

TPDB ID TPDB77477

Peptide_Name

RC-161

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 15-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation Chemical: Cys2-Cys7

Sequence

Ac-fCYwKVCT-NH2

FASTA

>TPDB77477|Blood-Brain Barrier|length=15
Ac-fCYwKVCT-NH2

Formula C66H91N17O16S3

Absent Amino Acids RDEQGILMPS

Common Amino Acids C

Mass 1474.73

PI 8.01

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +1

Boman Index -2.23

Hydrophobicity 0.187

Aliphatic Index 26.00

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 482.46

Polar Residues 6

number

1

A

0

R

1

N

0

D

3

C

0

E

0

Q

0

G

1

H

0

I

0

L

1

K

0

M

1

F

0

P

0

S

1

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 1

Length

15

Formula

C66H91N17O16S3

Mass

1474.73

PI

8.01

Net Charge

+1

Boman Index

-2.23

Hydrophobicity

0.187

Chemical_Modification

Cys2-Cys7

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Ac-(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Thr-NH2

SMILES

O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)C(O)C

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 53 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.000232 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0164 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 1.7 min

Assay & Model

Animal Model Origin/Source

Response half life, serum

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin human

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous