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Peptide record

TPDB77474

α Melanocyte stimula Blood-Brain Barrier modified_plain modified
16 amino acids
Basic Information
TPDB77474
α Melanocyte stimula
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 16-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
Ac-SYSMEHFRWGKPV
Physicochemical Analysis
C81H116N22O21S2
NDQILT
S
1798.07
8.88
3
1
6
+1
1.01
-0.481
24.38
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6990
388.75
4
Residue Composition
number
1
A
1
R
0
N
0
D
1
C
1
E
0
Q
1
G
1
H
0
I
0
L
1
K
1
M
1
F
1
P
2
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 1 M: 1 F: 1 P: 1 S: 2 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
16
C81H116N22O21S2
1798.07
8.88
+1
1.01
-0.481
Linear
Similarity
Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val
O=C(N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)C(C)C)CCC1)CCCCN)Cc3c2ccccc2nc3)CCCNC(=[N@H])N)Cc4ccccc4)Cc5ncnc5)CCC(=O)O)CCSC)CO)[C@@H](NC(=O)[C@H](NC(=O)C)CO)Cc6ccc(O)cc6
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
108

Assay & Model

Origin/Source
Blood/brain ratio

Source & Reference

NA
B3Pdb

Other

mouse,rat
Intracarotid injection
Permeability
Direct iodination
Additional Detail Fields 1 fields
Intracarotid injection