TPDB

TPDB ID TPDB77455

Peptide_Name

TP10-2

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 25-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

AGYLLGKINLKPLAALAKKIL-NH2

FASTA

>TPDB77455|Blood-Brain Barrier|length=25
AGYLLGKINLKPLAALAKKIL-NH2

Formula C116H199N31O27

Absent Amino Acids RDCEQMFSTWV

Common Amino Acids L

Mass 2460.05

PI 10.64

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 13

Net Charge +4

Boman Index 0.63

Hydrophobicity 0.380

Aliphatic Index 140.80

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 60.57

Polar Residues 3

number

4

A

0

R

2

N

0

D

0

C

0

E

0

Q

2

G

1

H

2

I

6

L

4

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 4 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 6 K: 4 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

25

Formula

C116H199N31O27

Mass

2460.05

PI

10.64

Net Charge

+4

Boman Index

0.63

Hydrophobicity

0.380

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Ala-Gly-Tyr-Leu-Leu-Gly-Lys-Ile-Asn-Leu-Lys-Pro-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0624 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 14.71%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 84.29%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.000359 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01007 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous