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Peptide record

TPDB77448

E-2078 Blood-Brain Barrier modified_plain modified
25 amino acids
Basic Information
TPDB77448
E-2078
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 25-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
(NMe)YGGFLR(NMe)Rl-NHC2H5
Physicochemical Analysis
C93H141N31O27S3
ADQIKPSTWV
N
2221.51
7.32
4
2
6
+0
4.97
-0.732
31.20
Mammalian: Yeast: E.coli:
1490
67.07
5
Residue Composition
number
0
A
2
R
3
N
0
D
1
C
2
E
0
Q
2
G
2
H
0
I
2
L
0
K
2
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 3 D: 0 C: 1 E: 2 Q: 0 G: 2 H: 2 I: 0 L: 2 K: 0 M: 2 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C93H141N31O27S3
2221.51
7.32
+0
4.97
-0.732
Linear
Similarity
(NMe)Tyr-Gly-Gly-Phe-Leu-Arg-(NMe)Arg-(D)Leu-NHC2H5
CCNC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)N(C)C(=O)[C@H](CCCN=C(N)N) NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H] (CC2=CC=C(C=C2)O)NCNA
Evidence Records 5 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
14.41%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
85.59%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00254 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(brain/perfusate)

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.000367 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(capillary/perfusate)

Source & Reference

NA
B3Pdb

Other

Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
0.00218 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(parenchyma/perfusate)

Source & Reference

NA
B3Pdb

Other

Direct iodination