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Peptide record

TPDB77445

Dmt1-Endomorphin 2 Blood-Brain Barrier modified_plain modified
13 amino acids
Basic Information
TPDB77445
Dmt1-Endomorphin 2
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 13-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation
Sequence
(Me2)YPFF-NH2
Physicochemical Analysis
C52H65N11O13S1
ARDCQGILKSTWV
F
1084.21
5.13
1
1
4
-1
0.42
-0.431
0.00
Mammalian: Yeast: E.coli:
1490
137.43
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
1
H
0
I
0
L
0
K
1
M
2
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 1 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C52H65N11O13S1
1084.21
5.13
-1
0.42
-0.431
Linear
Similarity
(Me2)Tyr-Pro-Phe-Phe-NH2
O=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3c(cc(O)cc3C)C)CCC4
Evidence Records 3 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
39.6 min

Assay & Model

HPLC
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

H3/C14
Evidence 2 Activity

Activity

Blood-Brain Barrier
1.183

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

H3/C14
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00001492 cm/s

Assay & Model

BMEC
Origin/Source
Permeability coefficientendoth

Source & Reference

NA
B3Pdb

Other

non saturable
H3/C14