TPDB

TPDB ID TPDB77444

Peptide_Name

P41

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 14-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

(Me2)Y-rFK-NH2

FASTA

>TPDB77444|Blood-Brain Barrier|length=14
(Me2)Y-rFK-NH2

Formula C50H73N15O13S1

Absent Amino Acids ADCQGILPSTWV

Common Amino Acids RNEHKMFY

Mass 1124.28

PI 9.74

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 3

Net Charge +1

Boman Index 2.90

Hydrophobicity -1.086

Aliphatic Index 0.00

Half Life

Mammalian: Yeast: E.coli:

Extinction Coefficient Cystines 1490

Absorbance 280nm 132.53

Polar Residues 2

number

0

A

1

R

1

N

0

D

0

C

1

E

0

Q

0

G

1

H

0

I

0

L

1

K

1

M

1

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 1 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

14

Formula

C50H73N15O13S1

Mass

1124.28

PI

9.74

Net Charge

+1

Boman Index

2.90

Hydrophobicity

-1.086

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

(Me2)Tyr-(D)Arg-Phe-Lys-NH2

SMILES

O=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)CCCCN

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 11.95 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin SMILES

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.058 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin SMILES

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 23.12%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin SMILES

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 76.88%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin SMILES

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00944 ml/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant,initial

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin SMILES

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01925 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin SMILES

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0003681 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin SMILES

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous