TPDB

TPDB ID TPDB77443

Peptide_Name

P42

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 17-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

(Me2)Y-rF-Nle-NH2

FASTA

>TPDB77443|Blood-Brain Barrier|length=17
(Me2)Y-rF-Nle-NH2

Formula C59H85N17O18S1

Absent Amino Acids ADCQGIKPSTWV

Common Amino Acids NE

Mass 1352.49

PI 5.30

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 4

Net Charge -1

Boman Index 3.79

Hydrophobicity -0.853

Aliphatic Index 22.94

Half Life

Mammalian: Yeast: E.coli:

Extinction Coefficient Cystines 1490

Absorbance 280nm 110.17

Polar Residues 3

number

0

A

1

R

2

N

0

D

0

C

2

E

0

Q

0

G

1

H

0

I

1

L

0

K

1

M

1

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

17

Formula

C59H85N17O18S1

Mass

1352.49

PI

5.30

Net Charge

-1

Boman Index

3.79

Hydrophobicity

-0.853

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

(Me2)Tyr-(D)Arg-Phe-Nle-NH2

SMILES

O=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=[N@H])N)Cc2ccccc2)CCCCC

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.039 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 32.97%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 67.03%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00848 ml/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant,initial

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02743 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0002485 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous