TPDB

TPDB ID TPDB77442

Peptide_Name

P43

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 17-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

(Me2)Y-cit-FK-NH2

FASTA

>TPDB77442|Blood-Brain Barrier|length=17
(Me2)Y-cit-FK-NH2

Formula C57H84N14O16S2

Absent Amino Acids ARDQGLPSWV

Common Amino Acids NCEHIKMFTY

Mass 1285.50

PI 7.15

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 4

Net Charge +0

Boman Index 1.68

Hydrophobicity -0.259

Aliphatic Index 22.94

Half Life

Mammalian: Yeast: E.coli:

Extinction Coefficient Cystines 1490

Absorbance 280nm 115.91

Polar Residues 4

number

0

A

0

R

1

N

0

D

1

C

1

E

0

Q

0

G

1

H

1

I

0

L

1

K

1

M

1

F

0

P

0

S

1

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 1 M: 1 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0

Length

17

Formula

C57H84N14O16S2

Mass

1285.50

PI

7.15

Net Charge

+0

Boman Index

1.68

Hydrophobicity

-0.259

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

(Me2)Tyr-(D)cit-Phe-Lys-NH2

SMILES

O=C(N)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](N)Cc1c(cc(O)cc1C)C)CCCNC(=O)N)Cc2ccccc2)CCCCN

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 25.67 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.027 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 19.39%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 80.61%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01491 ml/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant,initial

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02712 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.0003098 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous