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Peptide record

TPDB77440

ANG1005 Blood-Brain Barrier modified_plain modified
107 amino acids
Basic Information
TPDB77440
ANG1005
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 107-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
(2'-N-succinimide-paclitaxel)TFFYGGSRG-(2'-N-succinimide-paclitaxel)KRNNF(2'-N-succinimide-paclitaxel)KTEEY
Physicochemical Analysis
C374H599N95O121S12
QHWV
I
8747.15
3.90
4
11
32
-7
13.19
0.239
71.21
Mammalian: Yeast: E.coli:
3480
39.78
28
Residue Composition
number
6
A
2
R
8
N
3
D
9
C
8
E
0
Q
3
G
0
H
12
I
6
L
2
K
3
M
3
F
3
P
4
S
5
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 6 R: 2 N: 8 D: 3 C: 9 E: 8 Q: 0 G: 3 H: 0 I: 12 L: 6 K: 2 M: 3 F: 3 P: 3 S: 4 T: 5 W: 0 Y: 2 V: 0
Chemical Descriptors
107
C374H599N95O121S12
8747.15
3.90
-7
13.19
0.239
Linear
Similarity
(2'-N-succinimide-paclitaxel)Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-(2'-N-succinimide-paclitaxel)Lys-Arg-Asn-Asn-Phe-(2'-N-succinimide-paclitaxel)Lys-Thr-Glu-Glu-Tyr
Evidence Records 3 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.9333 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(brain/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
H3/C14
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.3111 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(capillary/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
H3/C14
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.5037 ml/g

Assay & Model

Capillary deplition in situ b p
Origin/Source
CD(parenchyma/perfusate)

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
H3/C14