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Peptide record

TPDB77286

CIGB-300 Anticancer modified_plain modified
27 amino acids
Basic Information
TPDB77286
CIGB-300
Anticancer
Cancer-related peptides
CancerPPD 2.0
modified_plain
Yes
A 27-aa modified anticancer peptide sequence curated from CancerPPD 2.0, without an available 3D structural model.
Chemical: X = Beta- Alanine N-terminal: Biotinylated
Sequence
GRKKRRQRRRPPQ-X-CWMSPRHLGTC
Physicochemical Analysis
C124H212N52O29S3
ANDEIFYV
R
2991.56
12.53
10
0
3
+9
8.29
-1.733
14.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
188.03
6
Residue Composition
number
0
A
7
R
0
N
0
D
2
C
0
E
2
Q
2
G
1
H
0
I
1
L
2
K
1
M
0
F
3
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 2 E: 0 Q: 2 G: 2 H: 1 I: 0 L: 1 K: 2 M: 1 F: 0 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
27
C124H212N52O29S3
2991.56
12.53
+9
8.29
-1.733
Free
X = Beta- Alanine
L
Cyclic
Biotinylated
Anticancer
Synthetic
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
IC50 = 30 ± 5.3 µM
Anticancer
30

Target

Lung Cancer
NCI-H-460
Lung

Assay & Model

Crystal Violet assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.