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Peptide record

TPDB77268

MAC1/26 Anticancer modified_plain modified
20 amino acids
Basic Information
TPDB77268
MAC1/26
Anticancer
Cancer-related peptides
CancerPPD 2.0 Peptipedia SATPdb dbACP
modified_plain
Yes
A 20-aa modified anticancer peptide sequence curated from CancerPPD 2.0, Peptipedia, SATPdb, and other sources, without an available 3D structural model.
C-terminal: Amidation Chemical: AC6C = cyclohexyl-1-carboxylic acid
Sequence
GFGMA-(AC6C)-KLLKKVL-NH2
Physicochemical Analysis
C71H124N18O16S3
RNDEQHIPSTWY
LK
1582.06
9.80
3
0
8
+3
-0.80
0.820
83.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
7.90
2
Residue Composition
number
2
A
0
R
0
N
0
D
2
C
0
E
0
Q
2
G
0
H
0
I
3
L
3
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 3 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C71H124N18O16S3
1582.06
9.80
+3
-0.80
0.820
Amidation
AC6C = cyclohexyl-1-carboxylic acid
L
Linear
Free
Antimicrobial and Antifungal
Macropins and their analogs
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
IC50 = 8±2 µM
Anticancer
8

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 18±1 µM
Anticancer
18

Target

Colon Cancer
SW
Colon

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012
Evidence 3 Activity

Activity

IC50
IC50 = 9±2 µM
Anticancer
9

Target

Leukemia Cancer
CCRF-CEM
Blood

Assay & Model

MTT/MTS assay
48-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012