Back to search

Peptide record

TPDB72753

Neurotoxin standard
39 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72753
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 39-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
CFPPGIYCTPYLPCCWGICCGTCRNVCHLRIGKRATFQE
Physicochemical Analysis
C193H294N54O49S8
DMS
C
4411.27
8.10
5
1
12
+3
-0.40
0.205
60.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
8980
203.57
15
Residue Composition
number
1
A
3
R
1
N
0
D
8
C
1
E
1
Q
4
G
1
H
3
I
2
L
1
K
0
M
2
F
4
P
0
S
3
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 8 E: 1 Q: 1 G: 4 H: 1 I: 3 L: 2 K: 1 M: 0 F: 2 P: 4 S: 0 T: 3 W: 1 Y: 2 V: 1
Chemical Descriptors
39
C193H294N54O49S8
4411.27
8.10
+3
-0.40
0.205
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits the vertebrate voltage-gated potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus emaciatus (False virgin cone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits the vertebrate voltage-gated potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3..
Kappa-conotoxin-like Em11.10
cone snail
Conotoxin I2 superfamily
Evidence at transcript level
Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at transcript level
Conotoxin I2 superfamily
Kappa-conotoxin-like Em11.10
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail