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Peptide record

TPDB72748

Neurotoxin standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB72748
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 42-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
QGDRDQPADRNAVPRDVNPGRARRKLMKVLRESECPWKPWCG
Physicochemical Analysis
C207H336N72O60S3
HIFTY
R
4889.57
10.30
10
6
11
+4
16.18
-1.369
46.43
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
11125
227.53
7
Residue Composition
number
3
A
7
R
2
N
4
D
2
C
2
E
2
Q
3
G
0
H
0
I
2
L
3
K
1
M
0
F
5
P
1
S
0
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 7 N: 2 D: 4 C: 2 E: 2 Q: 2 G: 3 H: 0 I: 0 L: 2 K: 3 M: 1 F: 0 P: 5 S: 1 T: 0 W: 2 Y: 0 V: 3
Chemical Descriptors
42
C207H336N72O60S3
4889.57
10.30
+4
16.18
-1.369
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus monile (Necklace cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-Mo
cone snail
O2 superfamily, Contryphan family
Evidence at transcript level
Amidation D-amino acid Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:28152596}.
Additional Detail Fields 7 fields
Amidation D-amino acid Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
O2 superfamily, Contryphan family
Contryphan-Mo
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:28152596}.
cone snail