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Peptide record

TPDB72746

Neurotoxin standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB72746
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 40-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
SDGRNDAAKAFDLISSTVKKGCCSHPACAGNNQHICGRRR
Physicochemical Analysis
C171H283N63O56S4
EMWY
A
4245.76
9.25
9
3
10
+4
10.76
-0.722
49.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
250
5.89
13
Residue Composition
number
5
A
4
R
3
N
3
D
4
C
0
E
1
Q
4
G
2
H
2
I
1
L
3
K
0
M
1
F
1
P
4
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 4 N: 3 D: 3 C: 4 E: 0 Q: 1 G: 4 H: 2 I: 2 L: 1 K: 3 M: 0 F: 1 P: 1 S: 4 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
40
C171H283N63O56S4
4245.76
9.25
+4
10.76
-0.722
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin reversibly blocks neuronal nAChRs (alpha-3/beta-2 = alpha-6 or -3/beta-2 or -3 > alpha-3/beta-4 = alpha-4/beta-2). {ECO:0000269|PubMed:12114524}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus geographus (Geography cone) (Nubecula geographus)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin reversibly blocks neuronal nAChRs (alpha-3/beta-2 = alpha-6 or -3/beta-2 or -3 > alpha-3/beta-4 = alpha-4/beta-2)..
Alpha-conotoxin GIC
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin GIC
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail