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Peptide record

TPDB72745

Neurotoxin standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB72745
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 38-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
NLYQFGNMIQCTIPKRLSWSSFVDYGCYCGKGGSGTPV
Physicochemical Analysis
C186H278N48O54S4
AEH
G
4178.78
8.53
3
1
13
+2
-1.70
-0.126
56.32
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
10095
241.58
16
Residue Composition
number
0
A
1
R
2
N
1
D
3
C
0
E
2
Q
6
G
0
H
2
I
2
L
2
K
1
M
2
F
2
P
4
S
2
T
1
W
3
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 1 C: 3 E: 0 Q: 2 G: 6 H: 0 I: 2 L: 2 K: 2 M: 1 F: 2 P: 2 S: 4 T: 2 W: 1 Y: 3 V: 2
Chemical Descriptors
38
C186H278N48O54S4
4178.78
8.53
+2
-1.70
-0.126
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Calliophis bivirgatus (Blue Malaysian coral snake) (Maticora bivirgata)
Neurotoxin Presynaptic neurotoxin
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Phospholipase A2 isozyme I)
snake
Phospholipase A2 family, Group I subfamily
Evidence at protein level
Calcium Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Metal-binding Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group I subfamily
Phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (Phospholipase A2 isozyme I)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake