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Peptide record

TPDB72743

Neurotoxin standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB72743
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 38-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
VGKNVICIHSGQCLIPCIDAGMRFGICKNGICDCTPKG
Physicochemical Analysis
C167H279N49O48S7
EWY
CGI
3965.77
8.02
5
2
12
+2
4.60
0.439
89.74
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
375
9.46
11
Residue Composition
number
1
A
1
R
2
N
2
D
6
C
0
E
1
Q
6
G
1
H
6
I
1
L
3
K
1
M
1
F
2
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 2 C: 6 E: 0 Q: 1 G: 6 H: 1 I: 6 L: 1 K: 3 M: 1 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
38
C167H279N49O48S7
3965.77
8.02
+2
4.60
0.439
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium (Kv) channel and augments neurite extension via NGF/TrkA signaling pathway. {ECO:0000269|PubMed:33466524}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium (Kv) channel and augments neurite extension via NGF/TrkA signaling pathway..
Toxin BmK NSPK (Buthus martensii Karsch neurite-stimulating peptide targeting Kv channels)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:33466524}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Toxin BmK NSPK (Buthus martensii Karsch neurite-stimulating peptide targeting Kv channels)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:33466524}.
scorpion