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Peptide record

TPDB72742

Neurotoxin standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB72742
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 28-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
WFRSFKSYYGHHGSVYRPNEPNFRSFAS
Physicochemical Analysis
C160H215N45O41
DCQILMT
S
3424.74
10.26
6
1
10
+3
0.48
-1.068
13.93
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
9970
291.12
10
Residue Composition
number
1
A
3
R
2
N
0
D
0
C
1
E
0
Q
2
G
2
H
0
I
0
L
1
K
0
M
4
F
2
P
5
S
0
T
1
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 0 L: 0 K: 1 M: 0 F: 4 P: 2 S: 5 T: 0 W: 1 Y: 3 V: 1
Chemical Descriptors
28
C160H215N45O41
3424.74
10.26
+3
0.48
-1.068
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of human alpha-3-beta-2 nAChRs (IC(50)=566.2 nM). Irreversibly inhibits the acetylcholine-induced response on human alpha-7/CHRNA7 (55% inhibition at 5.6 uM) and alpha-3-beta-2/CHRNA3-CHRNB2 (91% inhibition) nAChRs. {ECO:0000269|PubMed:32592834}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Polystira nobilis (Sea snail) (Pleurotoma nobilis)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Potent inhibitor of human alpha-3-beta-2 nAChRs (IC(50)=566.2 nM). Irreversibly inhibits the acetylcholine-induced response on human alpha-7/CHRNA7 (55% inhibition at 5.6 uM) and alpha-3-beta-2/CHRNA3-CHRNB2 (91% inhibition) nAChRs..
Turritoxin F21-2 (Turripeptide F21-2)
other
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:32592834}.
Additional Detail Fields 6 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Turritoxin F21-2 (Turripeptide F21-2)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:32592834}.
other