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Peptide record

TPDB72741

Neurotoxin standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB72741
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 48-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
IIECFFSCEIEKDGKSKEGKPCKPKGDKDKDKKCSGGWRCKIKMCLKI
Physicochemical Analysis
C237H395N65O68S7
ANQHTYV
K
5467.56
9.15
14
8
10
+6
20.13
-0.894
48.75
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5875
107.45
9
Residue Composition
number
0
A
1
R
0
N
4
D
6
C
4
E
0
Q
5
G
0
H
5
I
1
L
13
K
1
M
2
F
2
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 4 C: 6 E: 4 Q: 0 G: 5 H: 0 I: 5 L: 1 K: 13 M: 1 F: 2 P: 2 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
48
C237H395N65O68S7
5467.56
9.15
+6
20.13
-0.894
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Is toxic to both insects and mammals. Induces reversible paralysis when injected into S.frugiperda larvae. Reduces both the amplitude and frequency of responses from muscle (GF-TTM and GF-DLM) pathways in the D.melanogaster giant fiber circuit, suggesting an action at the neuromuscular junction, which is mediated by glutamatergic receptors. In mice, intracranial injection of 30 ug causes increased urination, myoclonus, hypermotility with circular movements followed by respiratory and generalized seizures resulting in death within 25-35 minutes of injection. {ECO:0000250|UniProtKB:B3EWY4}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)
Neurotoxin
Is toxic to both insects and mammals. Induces reversible paralysis when injected into S.frugiperda larvae.
U1-theraphotoxin-Agm1a (U1-TRTX-Agm1a)
spider
Neurotoxin 12 (Hwtx-2) family, 01 (Ap1a) subfamily
Evidence at protein level
Disulfide bond Neurotoxin Oxidation Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:27436114}.
Additional Detail Fields 7 fields
Disulfide bond Neurotoxin Oxidation Secreted Toxin
Neurotoxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 01 (Ap1a) subfamily
U1-theraphotoxin-Agm1a (U1-TRTX-Agm1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:27436114}.
spider