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Peptide record

TPDB72740

Neurotoxin standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB72740
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 37-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
ESDGAHAKARADKPARSATNRQPGCCNNPACVKHRCG
Physicochemical Analysis
C153H254N60O51S4
ILMFWY
A
3878.31
9.25
9
3
8
+4
14.15
-1.138
26.76
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
250
6.45
11
Residue Composition
number
7
A
4
R
3
N
2
D
4
C
1
E
1
Q
3
G
2
H
0
I
0
L
3
K
0
M
0
F
3
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 7 R: 4 N: 3 D: 2 C: 4 E: 1 Q: 1 G: 3 H: 2 I: 0 L: 0 K: 3 M: 0 F: 0 P: 3 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
37
C153H254N60O51S4
3878.31
9.25
+4
14.15
-1.138
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). This toxin inhibits high voltage-activated (HVA) calcium channel currents in rat DRG neurons (13% inhibition at 1 uM toxin) probably by activating GABA(B) receptors (GABBR1 and/or GABBR2) (PubMed:26948522). {ECO:0000250|UniProtKB:P0CE73, ECO:0000269|PubMed:26948522}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus kinoshitai (Kinoshita's cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin G-protein coupled receptor impairing toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). This toxin inhibits high voltage-activated (HVA) calcium channel currents in rat DRG neurons (13% inhibition at 1 uM toxin) probably by activating GABA(B) receptors (GABBR1 and/or GABBR2) (PubMed:26948522)..
Alpha-conotoxin-like Kn1.2
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond G-protein coupled receptor impairing toxin Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond G-protein coupled receptor impairing toxin Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin G-protein coupled receptor impairing toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like Kn1.2
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail