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Peptide record

TPDB72738

Neurotoxin standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB72738
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 39-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
TFINVKCTSPKQCLKPCKDLYGPHAGEKCMNGKCKCYKP
Physicochemical Analysis
C189H306N52O52S7
RW
K
4363.25
9.15
9
2
9
+6
9.58
-0.679
40.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
3355
76.89
14
Residue Composition
number
1
A
0
R
2
N
1
D
6
C
1
E
1
Q
3
G
1
H
1
I
2
L
8
K
1
M
1
F
4
P
1
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 1 C: 6 E: 1 Q: 1 G: 3 H: 1 I: 1 L: 2 K: 8 M: 1 F: 1 P: 4 S: 1 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
39
C189H306N52O52S7
4363.25
9.15
+6
9.58
-0.679
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks human voltage-gated potassium (Kv) channels Kv1.1/KCNA1 (Kd=1.5 uM), Kv1.2/KCNA2 (Kd=0.125 nM) and Kv1.3/KCNA3 (Kd=21.7 nM). {ECO:0000269|PubMed:37624263}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides bonito (Scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks human voltage-gated potassium (Kv) channels Kv1.1/KCNA1 (Kd=1.5 uM), Kv1.2/KCNA2 (Kd=0.125 nM) and Kv1.3/KCNA3 (Kd=21.7 nM)..
Potassium channel toxin alpha-KTx 2.23 (CboK4)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.23 (CboK4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37624263}.
scorpion