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Peptide record

TPDB72735

Neurotoxin standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB72735
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 47-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
IIECFFSCEIEKDGKSKEGKPCKPKGDKDKDKKCGGWRCKIKMCIKI
Physicochemical Analysis
C234H390N64O66S7
ANQHLTYV
K
5380.48
9.15
14
8
10
+6
20.25
-0.881
49.79
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5875
109.19
8
Residue Composition
number
0
A
1
R
0
N
4
D
6
C
4
E
0
Q
5
G
0
H
6
I
0
L
13
K
1
M
2
F
2
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 4 C: 6 E: 4 Q: 0 G: 5 H: 0 I: 6 L: 0 K: 13 M: 1 F: 2 P: 2 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
47
C234H390N64O66S7
5380.48
9.15
+6
20.25
-0.881
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Is toxic to insects. Reduces amplitude and frequency of spontaneous firing and inhibits voltage-gated sodium current (Nav) in the dorsal unpaired median (DUM) neurons of P.americana. {ECO:0000269|PubMed:23651762}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Acanthoscurria natalensis (Tarantula spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Is toxic to insects. Reduces amplitude and frequency of spontaneous firing and inhibits voltage-gated sodium current (Nav) in the dorsal unpaired median (DUM) neurons of P.americana..
Mu-theraphotoxin-An1a (Mu-TRTX-An1a)
spider
Neurotoxin 12 (Hwtx-2) family, 01 (Ap1a) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:23651762}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 01 (Ap1a) subfamily
Mu-theraphotoxin-An1a (Mu-TRTX-An1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:23651762}.
spider