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Peptide record

TPDB72732

Neurotoxin standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB72732
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 46-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
QVMVQGDGDQPAARNAVPKDDNPGGEAGKFMNVLRRSGCPWEPWCG
Physicochemical Analysis
C210H323N65O66S4
HITY
G
4942.51
4.72
5
6
14
-1
12.09
-0.811
42.39
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
11125
225.09
9
Residue Composition
number
4
A
3
R
3
N
4
D
2
C
2
E
3
Q
7
G
0
H
0
I
1
L
2
K
2
M
1
F
5
P
1
S
0
T
2
W
0
Y
4
V
Amino Acid Distribution
A: 4 R: 3 N: 3 D: 4 C: 2 E: 2 Q: 3 G: 7 H: 0 I: 0 L: 1 K: 2 M: 2 F: 1 P: 5 S: 1 T: 0 W: 2 Y: 0 V: 4
Chemical Descriptors
46
C210H323N65O66S4
4942.51
4.72
-1
12.09
-0.811
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus caracteristicus (Characteristic cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-C (Ca-75)
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17902199}.
Additional Detail Fields 7 fields
Amidation D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Contryphan-C (Ca-75)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17902199}.
cone snail