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Peptide record

TPDB72731

Neurotoxin standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB72731
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 38-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
APAKRWFGHEECTYWLGPCEVDDTCCSASCESKFCGLW
Physicochemical Analysis
C189H268N48O57S6
NQIM
C
4316.85
4.43
4
6
12
-3
4.14
-0.287
36.05
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
18365
425.43
12
Residue Composition
number
3
A
1
R
0
N
2
D
6
C
4
E
0
Q
3
G
1
H
0
I
2
L
2
K
0
M
2
F
2
P
3
S
2
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 2 C: 6 E: 4 Q: 0 G: 3 H: 1 I: 0 L: 2 K: 2 M: 0 F: 2 P: 2 S: 3 T: 2 W: 3 Y: 1 V: 1
Chemical Descriptors
38
C189H268N48O57S6
4316.85
4.43
-3
4.14
-0.287
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Induces a sleep-like state in mice. {ECO:0000269|PubMed:15379573}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin
Induces a sleep-like state in mice..
Conotoxin r7a (Light sleeper)
cone snail
Conotoxin O2 superfamily
Evidence at protein level
Bromination Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Bromination Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Knottin Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin O2 superfamily
Conotoxin r7a (Light sleeper)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail