Back to search

Peptide record

TPDB72727

Neurotoxin standard
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72727
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 36-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
AAAISCVGSPECPPKCRAQGCKNGKCMNRKCECYYC
Physicochemical Analysis
C156H255N49O48S9
DHLFTW
C
3873.58
8.31
6
2
9
+4
7.73
-0.403
30.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3480
89.84
15
Residue Composition
number
4
A
2
R
2
N
0
D
8
C
2
E
1
Q
3
G
0
H
1
I
0
L
4
K
1
M
0
F
3
P
2
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 4 R: 2 N: 2 D: 0 C: 8 E: 2 Q: 1 G: 3 H: 0 I: 1 L: 0 K: 4 M: 1 F: 0 P: 3 S: 2 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
36
C156H255N49O48S9
3873.58
8.31
+4
7.73
-0.403
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-gated potassium channel inhibitor. Selectively and irreversibly binds (K(d)=2.9 pM) and blocks hKv1.3/KCNA3 potassium channels of human T-lymphocytes. Weakly blocks hKCa3.1/KCNN4, mKv1.1/KCNA1, and hKv1.2/KCNA2 channels. In vivo, high doses (200 ug) produce no symptoms of intoxication when injected into mice. {ECO:0000269|PubMed:22540187, ECO:0000269|PubMed:22622363, ECO:0000269|Ref.1}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Vaejovis mexicanus smithi (Mexican scorpion) (Vaejovis smithi)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Voltage-gated potassium channel inhibitor. Selectively and irreversibly binds (K(d)=2.9 pM) and blocks hKv1.3/KCNA3 potassium channels of human T-lymphocytes.
Potassium channel toxin alpha-KTx 23.1 (Toxin Vm24) (Toxin alpha-KTx 21.1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 23 subfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22540187, ECO:0000305|PubMed:22622363, ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 23 subfamily
Potassium channel toxin alpha-KTx 23.1 (Toxin Vm24) (Toxin alpha-KTx 21.1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22540187, ECO:0000305|PubMed:22622363, ECO:0000305|Ref.1}.
scorpion