TPDB

3D PDB MODEL

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TPDB ID TPDB72706

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 328-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MKLLVLGTGGTIASAKTEMGYKAALSADDILQLAGIRREDGAKIETRDILNLDSTLIQPEDWVTIGRAVFEAFDEYDGIVITHGTDTLAYTSSALSFMIRNPPIPVVLTGSMLPITEPNSDAPRNLRTALTFARKGFPGIYVAFMDKIMLGTRVSKVHSLGLNAFQSINYPDIAYVKGDEVLVRHKPRIGNGEPLFDPELDPNVVHIRLTPGLSPEVLRAVARATDGIVLEGYGAGGIPYRGRNLLEVVSETAREKPVVMTTQALYGGVDLTRYEVGRRALEAGVIPAGDMTKEATLTKLMWALGHTRDLEEIRKIMERNIAGEITGS

FASTA

>TPDB72706|Neurotoxin|length=328
MKLLVLGTGGTIASAKTEMGYKAALSADDILQLAGIRREDGAKIETRDILNLDSTLIQPEDWVTIGRAVFEAFDEYDGIVITHGTDTLAYTSSALSFMIRNPPIPVVLTGSMLPITEPNSDAPRNLRTALTFARKGFPGIYVAFMDKIMLGTRVSKVHSLGLNAFQSINYPDIAYVKGDEVLVRHKPRIGNGEPLFDPELDPNVVHIRLTPGLSPEVLRAVARATDGIVLEGYGAGGIPYRGRNLLEVVSETAREKPVVMTTQALYGGVDLTRYEVGRRALEAGVIPAGDMTKEATLTKLMWALGHTRDLEEIRKIMERNIAGEITGS

Formula C1587H2566N436O475S10

Absent Amino Acids C

Common Amino Acids L

Mass 35675.07

PI 5.57

Basic Residues 41

Acidic Residues 41

Hydrophobic Residues 142

Net Charge -5

Boman Index 70.03

Hydrophobicity -0.038

Aliphatic Index 100.21

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 25900

Absorbance 280nm 72.60

Polar Residues 64

number

29

A

23

R

10

N

19

D

0

C

22

E

4

Q

32

G

5

H

25

I

34

L

13

K

10

M

8

F

18

P

14

S

26

T

2

W

10

Y

24

V

Amino Acid Distribution

A: 29 R: 23 N: 10 D: 19 C: 0 E: 22 Q: 4 G: 32 H: 5 I: 25 L: 34 K: 13 M: 10 F: 8 P: 18 S: 14 T: 26 W: 2 Y: 10 V: 24

Length

328

Formula

C1587H2566N436O475S10

Mass

35675.07

PI

5.57

Net Charge

-5

Boman Index

70.03

Hydrophobicity

-0.038

Evidence 1 Activity

Source & Reference

Database Source NA