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Peptide record

TPDB72704

Neurotoxin standard
55 amino acids
Basic Information
3D PDB MODEL
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TPDB72704
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 55-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MMKFLLVLFLITITLITMAYSEEHGCIPPFQPCEGVNSRCCGLYVCFNKICLATP
Physicochemical Analysis
C280H441N65O73S9
DW
L
6174.51
6.76
4
3
26
-0
-0.25
0.838
104.55
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
54.34
17
Residue Composition
number
2
A
1
R
2
N
0
D
6
C
3
E
1
Q
3
G
1
H
5
I
7
L
2
K
3
M
4
F
4
P
2
S
4
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 6 E: 3 Q: 1 G: 3 H: 1 I: 5 L: 7 K: 2 M: 3 F: 4 P: 4 S: 2 T: 4 W: 0 Y: 2 V: 3
Chemical Descriptors
55
C280H441N65O73S9
6174.51
6.76
-0
-0.25
0.838
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P58608}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Platymeris rhadamanthus (Red spot assassin bug)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav)..
U-reduvitoxin-Pr2a (U-RDTX-Pr2a) [Cleaved into: U-reduvitoxin-Pr2b (U-RDTX-Pr2b)]
insect
Venom Ptu1-like knottin family
Evidence at protein level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland (posterior main gland) (at protein level). {ECO:0000305|PubMed:31752210}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Venom Ptu1-like knottin family
U-reduvitoxin-Pr2a (U-RDTX-Pr2a) [Cleaved into: U-reduvitoxin-Pr2b (U-RDTX-Pr2b)]
TISSUE SPECIFICITY: Expressed by the venom gland (posterior main gland) (at protein level). {ECO:0000305|PubMed:31752210}.
insect