TPDB

3D PDB MODEL

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TPDB ID TPDB72695

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 296-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MKDKLVKAIAKDGQVRIIGAITTELVNEGVRLHNCAPTAAAALGRMLTAGALMGTTLKSEKDTLTLQIHGGGIAKGVVITSYADGHVKGYIGNPTADIEPNSKGKLDVSGIIGKNGNLLVIRDMGLKEPYIGQVPIYTGEIGEDLAYYYTVSEQTPSAVGLGVLVDKDLSIKSAGGFIIQMMPGADEMLADLISYRLEEIPSITEMISKGMTIEEILEYIFEDMDLKILESIVPEYRCDCSREKVERALASIGQKDLKEIYDEGKEEELKCHFCNKAYVFSHDEVGDILENYYSEK

FASTA

>TPDB72695|Neurotoxin|length=296
MKDKLVKAIAKDGQVRIIGAITTELVNEGVRLHNCAPTAAAALGRMLTAGALMGTTLKSEKDTLTLQIHGGGIAKGVVITSYADGHVKGYIGNPTADIEPNSKGKLDVSGIIGKNGNLLVIRDMGLKEPYIGQVPIYTGEIGEDLAYYYTVSEQTPSAVGLGVLVDKDLSIKSAGGFIIQMMPGADEMLADLISYRLEEIPSITEMISKGMTIEEILEYIFEDMDLKILESIVPEYRCDCSREKVERALASIGQKDLKEIYDEGKEEELKCHFCNKAYVFSHDEVGDILENYYSEK

Formula C1429H2305N367O450S15

Absent Amino Acids W

Common Amino Acids GI

Mass 32308.11

PI 4.62

Basic Residues 36

Acidic Residues 47

Hydrophobic Residues 124

Net Charge -16

Boman Index 81.44

Hydrophobicity -0.099

Aliphatic Index 99.83

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 21110

Absorbance 280nm 65.34

Polar Residues 64

number

21

A

8

R

8

N

19

D

5

C

28

E

6

Q

30

G

5

H

30

I

27

L

23

K

10

M

4

F

9

P

16

S

15

T

0

W

14

Y

18

V

Amino Acid Distribution

A: 21 R: 8 N: 8 D: 19 C: 5 E: 28 Q: 6 G: 30 H: 5 I: 30 L: 27 K: 23 M: 10 F: 4 P: 9 S: 16 T: 15 W: 0 Y: 14 V: 18

Length

296

Formula

C1429H2305N367O450S15

Mass

32308.11

PI

4.62

Net Charge

-16

Boman Index

81.44

Hydrophobicity

-0.099

Evidence 1 Activity

Source & Reference

Database Source NA