TPDB

3D PDB MODEL

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TPDB ID TPDB72677

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 297-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MVEVRVPATSANIGPGFDCLGVAVNMYNKFFVEEIEEGLIFEGCADKFKNENNLIYVAMKKCFDKIGYKPTGLRIKIESDIPVSRGLGSSAACVVGGIVSANELAGGALNKKELLDLAVEVEGHPDNVNPAFCGGMTASISDNREVIYSKVKVSEGIKFCALIPDFTLSTEKARAVLPKSIDYKDGIFNVGRTALMISALNNGDFHLIKYACKDKLHQDYRAKLIENFYSIKKQCEKLNSLGVFLSGAGPTIMVMLREEDKDFSKNIKSFLETLKNKWEVRELKIDKLGTVVNNCKV

FASTA

>TPDB72677|Neurotoxin|length=297
MVEVRVPATSANIGPGFDCLGVAVNMYNKFFVEEIEEGLIFEGCADKFKNENNLIYVAMKKCFDKIGYKPTGLRIKIESDIPVSRGLGSSAACVVGGIVSANELAGGALNKKELLDLAVEVEGHPDNVNPAFCGGMTASISDNREVIYSKVKVSEGIKFCALIPDFTLSTEKARAVLPKSIDYKDGIFNVGRTALMISALNNGDFHLIKYACKDKLHQDYRAKLIENFYSIKKQCEKLNSLGVFLSGAGPTIMVMLREEDKDFSKNIKSFLETLKNKWEVRELKIDKLGTVVNNCKV

Formula C1461H2344N384O431S16

Absent Amino Acids

Common Amino Acids K

Mass 32697.96

PI 7.77

Basic Residues 43

Acidic Residues 38

Hydrophobic Residues 125

Net Charge +2

Boman Index 69.14

Hydrophobicity -0.063

Aliphatic Index 94.51

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 17920

Absorbance 280nm 54.80

Polar Residues 66

number

21

A

9

R

20

N

16

D

9

C

22

E

2

Q

24

G

3

H

22

I

26

L

31

K

7

M

15

F

9

P

18

S

9

T

1

W

8

Y

25

V

Amino Acid Distribution

A: 21 R: 9 N: 20 D: 16 C: 9 E: 22 Q: 2 G: 24 H: 3 I: 22 L: 26 K: 31 M: 7 F: 15 P: 9 S: 18 T: 9 W: 1 Y: 8 V: 25

Length

297

Formula

C1461H2344N384O431S16

Mass

32697.96

PI

7.77

Net Charge

+2

Boman Index

69.14

Hydrophobicity

-0.063

Evidence 1 Activity

Source & Reference

Database Source NA