TPDB

3D PDB MODEL

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TPDB ID TPDB72673

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 290-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MEKRYELNKNLAQMLKDGVIMDVVNPEQAKIAEEAGAVAVMALERVPSDIRKQGGVARTSDPKMIKEIINAVSIPVMAKVRIGHFVEAQILEAIGVDYIDESEVLTPADDLFHINKKDFKVPFVCGARNLGEALRRIGEGASMIRTKGEAGTGNVVEAVRHMRTISSEMRKLQLTPKEELMTVAKEMGAPFNLIEYVAEKGRLPVINFAAGGIATPADAALMMQLGCDGIFVGSGIFKSDNPEKRAKAIVKATTYFKDPEVLAKASENLGGAMLGLEISKLETEFAERGW

FASTA

>TPDB72673|Neurotoxin|length=290
MEKRYELNKNLAQMLKDGVIMDVVNPEQAKIAEEAGAVAVMALERVPSDIRKQGGVARTSDPKMIKEIINAVSIPVMAKVRIGHFVEAQILEAIGVDYIDESEVLTPADDLFHINKKDFKVPFVCGARNLGEALRRIGEGASMIRTKGEAGTGNVVEAVRHMRTISSEMRKLQLTPKEELMTVAKEMGAPFNLIEYVAEKGRLPVINFAAGGIATPADAALMMQLGCDGIFVGSGIFKSDNPEKRAKAIVKATTYFKDPEVLAKASENLGGAMLGLEISKLETEFAERGW

Formula C1392H2276N382O416S16

Absent Amino Acids

Common Amino Acids A

Mass 31532.65

PI 5.73

Basic Residues 41

Acidic Residues 41

Hydrophobic Residues 130

Net Charge -3

Boman Index 83.78

Hydrophobicity -0.073

Aliphatic Index 93.55

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 11585

Absorbance 280nm 36.74

Polar Residues 45

number

34

A

15

R

11

N

13

D

2

C

28

E

6

Q

25

G

3

H

22

I

21

L

23

K

14

M

10

F

12

P

11

S

11

T

1

W

4

Y

24

V

Amino Acid Distribution

A: 34 R: 15 N: 11 D: 13 C: 2 E: 28 Q: 6 G: 25 H: 3 I: 22 L: 21 K: 23 M: 14 F: 10 P: 12 S: 11 T: 11 W: 1 Y: 4 V: 24

Length

290

Formula

C1392H2276N382O416S16

Mass

31532.65

PI

5.73

Net Charge

-3

Boman Index

83.78

Hydrophobicity

-0.073

Evidence 1 Activity

Source & Reference

Database Source NA