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Peptide record

TPDB72670

Neurotoxin standard
62 amino acids
Basic Information
3D PDB MODEL
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TPDB72670
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 62-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
ACQLITAEDSRGTQLHRALRSTSKVSKSTSCVEAGSYCRPNVKLCCGFCSPYSKICMNFPKN
Physicochemical Analysis
C285H466N86O89S8
W
S
6777.84
8.93
10
3
18
+6
10.57
-0.295
58.23
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
3355
49.50
27
Residue Composition
number
4
A
4
R
3
N
1
D
7
C
2
E
2
Q
3
G
1
H
2
I
4
L
5
K
1
M
2
F
3
P
9
S
4
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 4 R: 4 N: 3 D: 1 C: 7 E: 2 Q: 2 G: 3 H: 1 I: 2 L: 4 K: 5 M: 1 F: 2 P: 3 S: 9 T: 4 W: 0 Y: 2 V: 3
Chemical Descriptors
62
C285H466N86O89S8
6777.84
8.93
+6
10.57
-0.295
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus bullatus (Bubble cone)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav)..
Omega-conotoxin-like Bu11
cone snail
Conotoxin O1 superfamily
Evidence at transcript level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at transcript level
Conotoxin O1 superfamily
Omega-conotoxin-like Bu11
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail