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Peptide record

TPDB72660

Neurotoxin standard
114 amino acids
Basic Information
3D PDB MODEL
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TPDB72660
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 114-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MCVATCLCTFAYVLAKSDEGENLISKVEETQRGCIEIGGDCDGYLDKSYCQCCRNNGFCSCYKVPEWFGYKVGCKCSVDWNFVGWCRLKQFCPGGSQNPSLCKDPNPRRRRHGK
Physicochemical Analysis
C553H849N159O164S16
C
12861.75
7.88
17
12
33
+3
19.54
-0.456
51.23
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
24825
193.01
40
Residue Composition
number
3
A
7
R
6
N
6
D
15
C
6
E
4
Q
12
G
1
H
3
I
6
L
9
K
1
M
5
F
5
P
7
S
3
T
3
W
5
Y
7
V
Amino Acid Distribution
A: 3 R: 7 N: 6 D: 6 C: 15 E: 6 Q: 4 G: 12 H: 1 I: 3 L: 6 K: 9 M: 1 F: 5 P: 5 S: 7 T: 3 W: 3 Y: 5 V: 7
Chemical Descriptors
114
C553H849N159O164S16
12861.75
7.88
+3
19.54
-0.456
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated calcium channels (Cav). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelena orientalis (Funnel-web spider)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits voltage-gated calcium channels (Cav)..
U10-agatoxin-Ao1a (U10-AGTX-Ao1a) (AgorTX_B7b)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at transcript level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at transcript level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
U10-agatoxin-Ao1a (U10-AGTX-Ao1a) (AgorTX_B7b)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider