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Peptide record

TPDB72659

Neurotoxin standard
64 amino acids
Basic Information
3D PDB MODEL
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TPDB72659
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 64-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
LTCKTCPFTTCPNSESCPGGQSICYQRKWEEHRGERIERRCVANCPAFGSHDTSLLCCTRDNCN
Physicochemical Analysis
C295H465N95O97S10
M
C
7215.12
7.41
10
7
12
+1
17.47
-0.723
38.12
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
7615
105.54
28
Residue Composition
number
2
A
6
R
4
N
2
D
10
C
5
E
2
Q
4
G
2
H
2
I
3
L
2
K
0
M
2
F
4
P
5
S
6
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 4 D: 2 C: 10 E: 5 Q: 2 G: 4 H: 2 I: 2 L: 3 K: 2 M: 0 F: 2 P: 4 S: 5 T: 6 W: 1 Y: 1 V: 1
Chemical Descriptors
64
C295H465N95O97S10
7215.12
7.41
+1
17.47
-0.723
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Allosteric modulator of the GABA(A) receptor (GABR), possibly increasing receptor affinity for the agonist, thus enhancing receptor opening and macroscopic desensitization. In vivo, intracerebroventricular injection into mice results in periods of reduced basal activity, followed by bursts of intense seizures and death. {ECO:0000269|PubMed:25675485}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Micrurus mipartitus (Red-tailed coral snake)
Neurotoxin Chloride channel impairing toxin Ion channel impairing toxin
Allosteric modulator of the GABA(A) receptor (GABR), possibly increasing receptor affinity for the agonist, thus enhancing receptor opening and macroscopic desensitization. In vivo, intracerebroventricular injection into mice results in periods of reduced basal activity, followed by bursts of intense seizures and death..
Micrurotoxin 1 (MmTX1)
snake
Three-finger toxin family, Ancestral subfamily
Evidence at protein level
Chloride channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25675485}.
Additional Detail Fields 7 fields
Chloride channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Chloride channel impairing toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Ancestral subfamily
Micrurotoxin 1 (MmTX1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25675485}.
snake