Back to search

Peptide record

TPDB72656

Neurotoxin standard
89 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72656
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 89-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNCLMLIFVVFLLAFGVECKKDDYPVDTAKRNCMLDCNVWDDEGYCDKFCKGRKADSGYCYKLKAACYCYGLPDDSPTKTSGRCNPNVR
Physicochemical Analysis
C440H678N116O131S13
QH
DC
10105.70
7.37
13
12
33
+1
13.50
-0.308
60.22
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
15065
149.07
27
Residue Composition
number
5
A
4
R
5
N
10
D
10
C
2
E
0
Q
6
G
0
H
1
I
7
L
9
K
3
M
4
F
4
P
3
S
3
T
1
W
6
Y
6
V
Amino Acid Distribution
A: 5 R: 4 N: 5 D: 10 C: 10 E: 2 Q: 0 G: 6 H: 0 I: 1 L: 7 K: 9 M: 3 F: 4 P: 4 S: 3 T: 3 W: 1 Y: 6 V: 6
Chemical Descriptors
89
C440H678N116O131S13
10105.70
7.37
+1
13.50
-0.308
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated sodium channels (Nav). {ECO:0000305}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits voltage-gated sodium channels (Nav)..
Toxin To14 (T-alpha* NaTx3.10) (Toxin Tc41) (Toxin To41)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:15025998}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Toxin To14 (T-alpha* NaTx3.10) (Toxin Tc41) (Toxin To41)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:15025998}.
scorpion